ceesdekker.net for Dummies
ceesdekker.net for Dummies
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‘Sure, that is definitely about right. I seek out a Actual physical knowledge of Organic units inside a base-up way. I do think you can distinguish 3 strains of research in my group at this time. The initial problems chromosome composition: How can you get yourself a metre-very long DNA polymer folded and organised in this kind of microscopic cell? We've designed visualisation procedures that allow us to study how, by way of example, SMC proteins loop DNA (online video on Youtube) in order to Develop up chromosomes.
Our group studies bacterial mobile division which is aiming to represent a ‘bottom up biology’ in synthetic cells that may autonomously divide. Our primary curiosity lies in mobile division, chromatin framework, and spatial Management.
Back in 1991, Sumio Iijima from the NEC Corporation had noted the synthesis of carbon nanotubes. Band construction calculations advised that these nanotubes could exhibit metallic band conduction. This could be an important gain around the conducting polymers we experienced explored, which were being, in actual fact, disordered semiconductors featuring basically variable-vary hopping conductivity.
Due to the fact 2000, Dekker has shifted the primary concentration of his function toward biophysics where by he scientific studies the Houses of one biomolecules and cells using the resources of nanotechnology. This modification of industry was driven by his fascination to the extraordinary functioning of Organic molecular structures, along with because of the extensive-term perspective a large number of attention-grabbing discoveries can be expected On this discipline.[five] Latest strains of exploration in his biophysics team are during the parts of:[six]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review from the dynamics DNA supercoils and the invention of supercoil hopping
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You are a Christian. If you could make this kind of synthetic mobile, would you be a single step closer to God, or would the role of God have diminished rather once more?
Nanopores signify an elegant and flexible Instrument to measure single molecules. We research novel https://www.ceesdekker.net detection modes with strong-state nanopores as well as numerous methods to measure proteins with nanopores. Projects encompass the following:
‘You shouldn't just give thought to the questions of tomorrow, but also think about the concerns on the day right after tomorrow’
one). The current–voltage curves showed sizeable modulations with gate voltage, even at area temperature, which was in line with band bending in a very ~0.6 eV bandgap semiconducting nanotube. These knowledge also showed the conductance can be modulated by six orders of magnitude by transforming the gate voltage. The outcomes of the work — a area-temperature transistor made from an individual carbon nanotube molecule — were revealed in Mother nature in May 1998.
Tests pseudotopological and nontopological designs for SMC-pushed DNA loop extrusion versus roadblock-traversal experiments
Character Physics many thanks the nameless reviewers for their contribution to your peer overview of this get the job done.
As an example, we look at the nucleopore complex, a gateway concerning the mobile nucleus along with the cytoplasm. This is a very complicated procedure and for that reason hard to study in a very cell, so we use biomimetics. We reconstruct holes and then insert unique aspects from the nucleopore elaborate to review transport by it at The only-molecule amount.’
‘I'm pushed by wonder and queries. On a fabric stage I obtain responses in physics, but I encounter my deepest joy with God. That faith also drives my science And just how I manage people today.